STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemAGlutamyl-tRNA reductase, putative; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (417 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase, putative; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.997
hemL
Glutamate-1-semialdehyde 2,1-aminotransferase, putative; GC: 51.27%; Codon Adaptation Index (CAI): 0.772. Curator(s): M. Chaplin, T. Kitten; Protein involved in glutamate-1-semialdehyde 2,1-aminomutase activity.
 
 0.997
HemD
Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.974
SSA_0487
Delta-aminolevulinic acid dehydratase, putative; GC: 50.82%; Codon Adaptation Index (CAI): 0.781. Curator(s): M. Chaplin; Protein involved in lyase activity; Belongs to the ALAD family.
 
  
 0.968
SSA_0474
Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity.
 
  
 0.935
SSA_0483
Siroheme synthase, putative; GC: 50.46%; Codon Adaptation Index (CAI): 0.724. Curator(s): M. Chaplin; Protein involved in NAD binding.
 
   
 0.872
cobQ-2
Cobyric acid synthase, putative; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
     
 0.817
cobS
Cobalamin 5'-phosphate synthase, putative; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
     
 0.766
SSA_0480
Cobalt ABC transporter, ATP-binding protein, putative; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
     
 0.732
cobU
Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase, putative; GC: 53.5%; Codon Adaptation Index (CAI): 0.765. Curator(s): M. Chaplin, J. Alves; Protein involved in nucleotidyltransferase activity.
     
 0.729
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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