node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HemD | SSA_0474 | SSA_0486 | SSA_0474 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | 0.973 |
HemD | SSA_0483 | SSA_0486 | SSA_0483 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Siroheme synthase, putative; GC: 50.46%; Codon Adaptation Index (CAI): 0.724. Curator(s): M. Chaplin; Protein involved in NAD binding. | 0.862 |
HemD | SSA_0487 | SSA_0486 | SSA_0487 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Delta-aminolevulinic acid dehydratase, putative; GC: 50.82%; Codon Adaptation Index (CAI): 0.781. Curator(s): M. Chaplin; Protein involved in lyase activity; Belongs to the ALAD family. | 0.972 |
HemD | SSA_0491 | SSA_0486 | SSA_0491 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Alpha-ribazole-5'-phosphate phosphatase, putative; GC: 51.31%; Codon Adaptation Index (CAI): 0.754. Curator(s): M. Chaplin; Belongs to the phosphoglycerate mutase family. | 0.638 |
HemD | cobS | SSA_0486 | SSA_0490 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin 5'-phosphate synthase, putative; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.717 |
HemD | cobU | SSA_0486 | SSA_0489 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase, putative; GC: 53.5%; Codon Adaptation Index (CAI): 0.765. Curator(s): M. Chaplin, J. Alves; Protein involved in nucleotidyltransferase activity. | 0.727 |
HemD | hemA | SSA_0486 | SSA_0484 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamyl-tRNA reductase, putative; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.974 |
HemD | hemC | SSA_0486 | SSA_0485 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase, putative; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
HemD | hemL | SSA_0486 | SSA_0488 | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde 2,1-aminotransferase, putative; GC: 51.27%; Codon Adaptation Index (CAI): 0.772. Curator(s): M. Chaplin, T. Kitten; Protein involved in glutamate-1-semialdehyde 2,1-aminomutase activity. | 0.943 |
SSA_0474 | HemD | SSA_0474 | SSA_0486 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.973 |
SSA_0474 | SSA_0483 | SSA_0474 | SSA_0483 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Siroheme synthase, putative; GC: 50.46%; Codon Adaptation Index (CAI): 0.724. Curator(s): M. Chaplin; Protein involved in NAD binding. | 0.995 |
SSA_0474 | SSA_0487 | SSA_0474 | SSA_0487 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Delta-aminolevulinic acid dehydratase, putative; GC: 50.82%; Codon Adaptation Index (CAI): 0.781. Curator(s): M. Chaplin; Protein involved in lyase activity; Belongs to the ALAD family. | 0.991 |
SSA_0474 | SSA_0491 | SSA_0474 | SSA_0491 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Alpha-ribazole-5'-phosphate phosphatase, putative; GC: 51.31%; Codon Adaptation Index (CAI): 0.754. Curator(s): M. Chaplin; Belongs to the phosphoglycerate mutase family. | 0.443 |
SSA_0474 | cobS | SSA_0474 | SSA_0490 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Cobalamin 5'-phosphate synthase, putative; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.614 |
SSA_0474 | cobU | SSA_0474 | SSA_0489 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase, putative; GC: 53.5%; Codon Adaptation Index (CAI): 0.765. Curator(s): M. Chaplin, J. Alves; Protein involved in nucleotidyltransferase activity. | 0.682 |
SSA_0474 | hemA | SSA_0474 | SSA_0484 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Glutamyl-tRNA reductase, putative; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.935 |
SSA_0474 | hemC | SSA_0474 | SSA_0485 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Porphobilinogen deaminase, putative; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
SSA_0474 | hemL | SSA_0474 | SSA_0488 | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | Glutamate-1-semialdehyde 2,1-aminotransferase, putative; GC: 51.27%; Codon Adaptation Index (CAI): 0.772. Curator(s): M. Chaplin, T. Kitten; Protein involved in glutamate-1-semialdehyde 2,1-aminomutase activity. | 0.855 |
SSA_0483 | HemD | SSA_0483 | SSA_0486 | Siroheme synthase, putative; GC: 50.46%; Codon Adaptation Index (CAI): 0.724. Curator(s): M. Chaplin; Protein involved in NAD binding. | Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.862 |
SSA_0483 | SSA_0474 | SSA_0483 | SSA_0474 | Siroheme synthase, putative; GC: 50.46%; Codon Adaptation Index (CAI): 0.724. Curator(s): M. Chaplin; Protein involved in NAD binding. | Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. | 0.995 |