STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
gidBMethyltransferase gidB, putative; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (237 aa)    
Predicted Functional Partners:
gidA
Glucose inhibited division protein A, putative; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.
  
  
 0.943
trmE
tRNA modification GTPase, possibly iron-binding, putative; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
  
  
 0.906
gyrB
DNA gyrase, putative; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.747
SSA_2382
Chromosome partitioning protein ParB or transcriptional regulator Spo0J, putative; GC: 34.49%; Codon Adaptation Index (CAI): 0.781. Curator(s): J. Alves; Protein involved in plasmid partitioning (sensu Bacteria); Belongs to the ParB family.
  
  
 0.729
guaB
Inosine-5'-monophosphate dehydrogenase, putative; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.654
rpsL
30S ribosomal protein S12, putative; With S4 and S5 plays an important role in translational accuracy.
      
 0.652
jag
RNA-binding protein, Jag family, putative; GC: 45.81%; Codon Adaptation Index (CAI): 0.791. Curator(s): J. Alves; Protein involved in nucleic acid binding.
  
  
 0.652
SSA_1230
Conserved uncharacterized protein; GC: 48.73%; Codon Adaptation Index (CAI): 0.77.
  
  
 0.642
SSA_1889
Conserved uncharacterized protein; GC: 47.26%; Codon Adaptation Index (CAI): 0.753. Helix-turn-helix prediction: AraC. Curator(s): J. Alves.
  
  
 0.642
dfrA
Dihydrofolate reductase, putative; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
  
 0.640
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.