STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
trpDAnthranilate phosphoribosyltransferase, putative; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa)    
Predicted Functional Partners:
trpE
Anthranilate synthase component I, putative; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and hig [...]
 
 0.999
trpG
Anthranilate synthase component II, putative; GC: 45.21%; Codon Adaptation Index (CAI): 0.783. Curator(s): P. Xu; Protein involved in folic acid biosynthesis.
 
 0.999
trpC
Indole-3-glycerol phosphate synthase, putative; GC: 44.01%; Codon Adaptation Index (CAI): 0.77. Curator(s): P. Xu; Protein involved in tryptophan metabolism; Belongs to the TrpC family.
  
 0.999
trpF
N-(5'-phosphoribosyl)anthranilate isomerase, putative; GC: 48.9%; Codon Adaptation Index (CAI): 0.762. Curator(s): P. Xu; Protein involved in isomerase activity; Belongs to the TrpF family.
 
 0.999
trpA
Tryptophan synthase alpha chain, putative; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.992
trpB
Tryptophan synthase beta chain, putative; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.986
pabB
Anthranilate/para-aminobenzoate synthases component I/ Chorismate binding enzyme, putative; GC: 49.3%; Codon Adaptation Index (CAI): 0.761. Curator(s): M. Chaplin, J. Alves.
 
 
 0.981
trpB2
Tryptophan synthase beta chain, putative; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.949
ung
Uracil-DNA glycosylase, putative; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
      0.664
SSA_1183
Conserved hypothetical protein; GC: 42.8%; Codon Adaptation Index (CAI): 0.794.
  
  
 0.646
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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