STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folDMethylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)    
Predicted Functional Partners:
fhs
Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family.
 
 0.998
fhs1
Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis.
 
 0.996
glyA
Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 0.982
metF
5,10-methylenetetrahydrofolate reductase, putative; GC: 45.39%; Codon Adaptation Index (CAI): 0.772. Curator(s): M. Chaplin; Protein involved in oxidoreductase activity; Belongs to the methylenetetrahydrofolate reductase family.
    
 0.980
purN
Phosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.975
purH
Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves.
  
 
 0.972
thyA
Thymidylate synthase, putative; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.958
SSA_0433
Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin.
    
 0.943
nusB
Nitrogen utilization substance protein B, putative; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
  
  
 0.943
acoL
Dihydrolipoamide dehydrogenase, putative; GC: 45.81%; Codon Adaptation Index (CAI): 0.808; Protein involved in FAD binding.
    
 0.942
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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