node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSA_0433 | SSA_2171 | SSA_0433 | SSA_2171 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Conserved hypothetical protein; GC: 44.88%; Codon Adaptation Index (CAI): 0.783; Protein involved in 5-formyltetrahydrofolate cyclo-ligase activity and metabolism; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.926 |
SSA_0433 | fhs | SSA_0433 | SSA_1200 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | 0.919 |
SSA_0433 | fhs1 | SSA_0433 | SSA_0432 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis. | 0.973 |
SSA_0433 | fmt | SSA_0433 | SSA_1848 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Methionyl-tRNA formyltransferase, putative; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.916 |
SSA_0433 | folD | SSA_0433 | SSA_0671 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.937 |
SSA_0433 | purH | SSA_0433 | SSA_0035 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves. | 0.903 |
SSA_0433 | purN | SSA_0433 | SSA_0033 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Phosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.907 |
SSA_2171 | SSA_0433 | SSA_2171 | SSA_0433 | Conserved hypothetical protein; GC: 44.88%; Codon Adaptation Index (CAI): 0.783; Protein involved in 5-formyltetrahydrofolate cyclo-ligase activity and metabolism; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | 0.926 |
SSA_2171 | folD | SSA_2171 | SSA_0671 | Conserved hypothetical protein; GC: 44.88%; Codon Adaptation Index (CAI): 0.783; Protein involved in 5-formyltetrahydrofolate cyclo-ligase activity and metabolism; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.937 |
SSA_2171 | glyA | SSA_2171 | SSA_1155 | Conserved hypothetical protein; GC: 44.88%; Codon Adaptation Index (CAI): 0.783; Protein involved in 5-formyltetrahydrofolate cyclo-ligase activity and metabolism; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.445 |
SSA_2171 | purN | SSA_2171 | SSA_0033 | Conserved hypothetical protein; GC: 44.88%; Codon Adaptation Index (CAI): 0.783; Protein involved in 5-formyltetrahydrofolate cyclo-ligase activity and metabolism; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.913 |
fhs | SSA_0433 | SSA_1200 | SSA_0433 | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | 0.919 |
fhs | fhs1 | SSA_1200 | SSA_0432 | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis. | 0.902 |
fhs | folD | SSA_1200 | SSA_0671 | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
fhs | glyA | SSA_1200 | SSA_1155 | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
fhs | metF | SSA_1200 | SSA_0417 | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate reductase, putative; GC: 45.39%; Codon Adaptation Index (CAI): 0.772. Curator(s): M. Chaplin; Protein involved in oxidoreductase activity; Belongs to the methylenetetrahydrofolate reductase family. | 0.695 |
fhs | purH | SSA_1200 | SSA_0035 | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves. | 0.964 |
fhs | purN | SSA_1200 | SSA_0033 | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.951 |
fhs1 | SSA_0433 | SSA_0432 | SSA_0433 | Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis. | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | 0.973 |
fhs1 | fhs | SSA_0432 | SSA_1200 | Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis. | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | 0.902 |