STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
holAConserved hypothetical protein; GC: 41.93%; Codon Adaptation Index (CAI): 0.805. Helix-turn-helix prediction: AraC. Curator(s): X. Ge; Protein involved in DNA replication. (348 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...]
  
 
 0.993
dnaX
DNA-directed DNA polymerase III chain, putative; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.992
holB
DNA polymerase III, delta' subunit, putative; GC: 44.89%; Codon Adaptation Index (CAI): 0.795; Protein involved in 3'-5' exonuclease activity.
  
 
 0.992
dnaE
DNA-polymerase III alpha-chain, putative; GC: 46.17%; Codon Adaptation Index (CAI): 0.784. Curator(s): L. Ozaki; Protein involved in 3'-5' exonuclease activity and nucleotidyltransferase activity.
  
 0.990
polC
DNA polymerase III polC-type, putative; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
 0.942
polA
DNA polymerase I - 3'-5' exonuclease and polymerase domains, putative; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.775
comEC
Competence protein, putative; GC: 43.24%; Transporter classification TC:3.A.11.1.1. Transmembrane domains: 9. Codon Adaptation Index (CAI): 0.763. Helix-turn-helix prediction: AraC. Curator(s): X. Ge, J. Alves; Protein involved in establishment of competence for transformation.
 
   
 0.767
sodA
Mn/Fe-dependent superoxide dismutase, putative; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
       0.757
SSA_0722
Conserved hypothetical protein; GC: 42.29%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.777. Curator(s): X. Ge, J. Alves; possible membrane-associated peptidase; Protein involved in proteolysis.
       0.690
SSA_0718
Conserved uncharacterized protein; GC: 41.64%; Transmembrane domains: 3. Codon Adaptation Index (CAI): 0.823. Possibly membrane-associated, QG-rich protein. Curator(s): X. Ge.
       0.585
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.