STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
queAS-adenosylmethio nine:tRNA-ribosyltransferase-isomerase (queuine synthetase), putative; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa)    
Predicted Functional Partners:
tgt
Queuine tRNA-ribosyltransferase, putative; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose [...]
 
 
 0.984
arcC
Carbamate kinase, putative; GC: 45.68%; Codon Adaptation Index (CAI): 0.795. SignalP prediction: Yes (prob. 0.989); Curator(s): X. Ge; Protein involved in transferase activity; Belongs to the carbamate kinase family.
      
 0.818
SSA_0506
Iron-sulfur cluster-binding protein, putative; GC: 48.25%; Codon Adaptation Index (CAI): 0.753. Curator(s): D. Akan; Protein involved in 4 iron, 4 sulfur cluster binding.
 
  
 0.813
arcT
Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase, putative; GC: 48.8%; Codon Adaptation Index (CAI): 0.771. Curator(s): X. Ge, J. Alves; Protein involved in metallopeptidase activity.
   
  
 0.795
SSA_0745
Hypothetical protein; GC: 39.19%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.744. Curator(s): X. Ge.
       0.773
argR
Transcriptional repressor (arginine synthesis), putative; Regulates arginine biosynthesis genes.
     
 0.770
nagB
Glucosamine-6-phosphate deaminase, putative; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
       0.737
arc
Ornithine carbamoyltransferase, catabolic, putative; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
      
 0.692
ruvB
Holliday junction DNA helicase ruvB, putative; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
  
  
 0.689
SSA_0740
C4-dicarboxylate anaerobic carrier, possible arginine transporter, putative; GC: 44.71%; Transporter classification TC:9.B.50.1.1. Transmembrane domains: 11. Codon Adaptation Index (CAI): 0.783. SignalP prediction: Yes (prob. 1); Curator(s): X. Ge, J. Alves.
      
 0.681
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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