STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
nrdFRibonucleoside-diphosphate reductase 2, beta subunit, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa)    
Predicted Functional Partners:
nrdE
Ribonucleoside-diphosphate reductase, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
 0.999
nrdI
Ribonucleotide reductase (NrdI family protein), putative; GC: 43.56%; Codon Adaptation Index (CAI): 0.824. Curator(s): J. Alves; Belongs to the NrdI family.
 
 
 0.996
nrdH
Glutaredoxin-like protein, putative; GC: 39.27%; Codon Adaptation Index (CAI): 0.804. Involved in electron transport system for ribonucleotide reductase system NrdEF. Curator(s): X. Ge; Protein involved in cell redox homeostasis.
 
  
 0.982
SSA_1668
NrdI protein, putative; GC: 44.63%; Codon Adaptation Index (CAI): 0.813; Protein involved in molecular function unknown; Belongs to the NrdI family.
 
 
 0.934
tmk
Thymidylate kinase, putative; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.924
SSA_1683
NrdI protein, putative; GC: 45.7%; Codon Adaptation Index (CAI): 0.785; Protein involved in molecular function unknown; Belongs to the NrdI family.
  
 
 0.921
cmk
Cytidylate kinase, putative; GC: 44.69%; Codon Adaptation Index (CAI): 0.79; Protein involved in nucleotide kinase activity.
    
 0.919
adk
Adenylate kinase, putative; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.906
gmk
Guanylate kinase, putative; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.906
relA
GTP pyrophosphokinase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
   
 
  0.902
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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