Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
endADNA-entry nuclease, putative; GC: 49.94%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.757. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.969); Curator(s): X. Ge; Protein involved in endonuclease activity and establishment of competence for transformation. (286 aa)    
Predicted Functional Partners:
SSA_0794
Zn-dependent protease, putative; GC: 47.22%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.753. SignalP prediction: Yes (prob. 0.542); Curator(s): X. Ge; Protein involved in hydrolase activity and proteolysis.
 
     0.770
murA
UDP-N-acetylglucosamine-like protein, putative; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
     
 0.765
SSA_0792
Hypothetical protein; GC: 38.8%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.748. SignalP prediction: Yes (prob. 0.76); Curator(s): X. Ge.
       0.762
comFA
Superfamily II ATP-dependent DNA/RNA helicase; GC: 42.57%; Transporter classification TC:3.A.11.1.1. Codon Adaptation Index (CAI): 0.761. Curator(s): J. Alves; Protein involved in hydrolase activity.
      
 0.741
recA
RecA protein, putative; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.659
comEC
Competence protein, putative; GC: 43.24%; Transporter classification TC:3.A.11.1.1. Transmembrane domains: 9. Codon Adaptation Index (CAI): 0.763. Helix-turn-helix prediction: AraC. Curator(s): X. Ge, J. Alves; Protein involved in establishment of competence for transformation.
     
 0.649
SSA_1169
Conserved hypothetical protein with an alpha/beta hydrolase fold, putative; GC: 40.56%; Codon Adaptation Index (CAI): 0.776; Protein involved in hydrolase activity.
  
     0.635
cinA
Competence-damage protein, putative; GC: 47.33%; Codon Adaptation Index (CAI): 0.77. Helix-turn-helix prediction: AraC; Protein involved in Mo-molybdopterin cofactor biosynthesis and establishment of competence for transformation; Belongs to the CinA family.
     
 0.635
smf
DNA processing Smf protein, putative; GC: 42.11%; Codon Adaptation Index (CAI): 0.781; Protein involved in DNA mediated transformation.
      
 0.625
comEA
DNA uptake protein, putative; GC: 46.11%; Transporter classification TC:3.A.11.1.1. Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.777. SignalP prediction: Yes (prob. 0.536); Curator(s): X. Ge, J. Alves; Protein involved in establishment of competence for transformation.
      
 0.602
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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