STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SSA_0803Conserved hypothetical protein; GC: 45.5%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.773. LipoP prediction: SpI. SignalP prediction: Yes (prob. 1); Curator(s): X. Ge. (251 aa)    
Predicted Functional Partners:
dacA-2
Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
  
  
 0.946
glmM
Phosphoglucomutase/phosphomannomutase family protein, putative; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
  
  
 0.824
SSA_0801
Mur ligase family protein, putative; GC: 47.02%; Codon Adaptation Index (CAI): 0.776. LipoP prediction: SpI. Helix-turn-helix prediction: AraC. Curator(s): X. Ge; Protein involved in ligase activity.
 
     0.734
cobQ
Glutamine amidotransferase, putative; GC: 45.04%; Codon Adaptation Index (CAI): 0.762. Curator(s): X. Ge; Protein involved in cobalamin biosynthesis.
 
     0.733
ezrA
Cell division regulator, negative regulator of FtsZ septation ring formation, putative; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
     0.712
gpsB
Conserved DivIVA-like protein, putative; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
  
     0.640
comYC
Competence protein ComYC, putative; GC: 42.45%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.818. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.982); Curator(s): M. Serrano, J. Alves; Protein involved in type II protein secretion system.
  
     0.623
recU
Penicillin-binding protein-like factor A/ recombinase, putative; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family.
  
     0.545
SSA_1211
Conserved hypothetical protein; GC: 40.7%; Codon Adaptation Index (CAI): 0.764; Protein involved in cAMP biosynthesis.
  
     0.539
SSA_0799
Hypothetical protein; GC: 34.11%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.742. SignalP prediction: Yes (prob. 0.762); Curator(s): X. Ge.
       0.532
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.