Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sipSignal peptidase I, putative; GC: 39.43%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.762. Curator(s): L. Ozaki; Protein involved in hydrolase activity; Belongs to the peptidase S26 family. (185 aa)    
Predicted Functional Partners:
spi
Signal peptidase I, putative; GC: 45.56%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.781. SignalP prediction: Yes (prob. 0.646); Curator(s): T. Kitten; Belongs to the peptidase S26 family.
  
  
0.919
pykF
Pyruvate kinase I, fructose-stimulated, putative; GC: 42.36%; Codon Adaptation Index (CAI): 0.802. Curator(s): L. Ozaki; Protein involved in transferase activity and glycolysis; Belongs to the pyruvate kinase family.
     
 0.688
lepA
GTP-binding protein lepA, putative; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
 
 0.636
pfk
6-phosphofructokinase, putative; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
       0.634
scpB
Segregation and condensation protein B, putative; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
      
 0.615
dnaE
DNA-polymerase III alpha-chain, putative; GC: 46.17%; Codon Adaptation Index (CAI): 0.784. Curator(s): L. Ozaki; Protein involved in 3'-5' exonuclease activity and nucleotidyltransferase activity.
       0.538
rnh
Ribonuclease HII, putative; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
  
    0.538
SSA_1909
Transcriptional attenuator LytR, putative; GC: 44.71%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.813. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.997). Capsular polysaccharide biosynthesis transcriptional attenuator. Curator(s): J. Alves.
 
     0.507
SSA_0850
Ubiquitin C-terminal hydrolase, putative; GC: 33.33%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.796. LipoP prediction: SpII. SignalP prediction: Yes (prob. 1); Curator(s): L. Ozaki.
       0.489
cpsA
Transcriptional attenuator LytR, putative; GC: 43.61%; Transmembrane domains: 3. Codon Adaptation Index (CAI): 0.774. SignalP prediction: Yes (prob. 0.997). Capsular polysaccharide biosynthesis transcriptional attenuator. Curator(s): J. Alves; Protein involved in DNA replication.
 
     0.471
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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