Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SSA_0874Conserved membrane protein; GC: 44.34%; Transporter classification TC:9.B.63.1.2. Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.756. SignalP prediction: Yes (prob. 0.998); Curator(s): L. Ozaki, J. Alves; (possible metabolite efflux protein), putative. (326 aa)    
Predicted Functional Partners:
rodA
Rod shape determining protein (cell-cycle protein), putative; GC: 44.77%; Transporter classification TC:9.B.3.1.3. Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.775. Curator(s): L. Ozaki, J. Alves; Protein involved in cell division; Belongs to the SEDS family.
       0.841
thiJ
4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis protein, putative; GC: 47.18%; Codon Adaptation Index (CAI): 0.804. Curator(s): L. Ozaki.
       0.732
dinG
ATP-dependent DNA helicase; 3'-5' exonuclease.
       0.724
gyrB
DNA gyrase, putative; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.551
SSA_0877
Phosphoglycolate phosphatase, putative; GC: 43.58%; Codon Adaptation Index (CAI): 0.768. Curator(s): L. Ozaki; Protein involved in hydrolase activity.
       0.532
SSA_0872
Zn-dependent hydrolases, including glyoxylases, putative; GC: 45.85%; Codon Adaptation Index (CAI): 0.773. Curator(s): L. Ozaki.
       0.499
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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