Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ezrACell division regulator, negative regulator of FtsZ septation ring formation, putative; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (574 aa)    
Predicted Functional Partners:
gpsB
Conserved DivIVA-like protein, putative; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
  
 
 0.912
rodA
Rod shape determining protein (cell-cycle protein), putative; GC: 44.77%; Transporter classification TC:9.B.3.1.3. Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.775. Curator(s): L. Ozaki, J. Alves; Protein involved in cell division; Belongs to the SEDS family.
 
   
 0.892
divIB
Cell division protein DivIB, putative; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily.
  
   
 0.888
pbpX
Penicillin-binding protein 2X, putative; GC: 45.35%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.791. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.924); Protein involved in cell division and cell wall biosynthesis (sensu Bacteria).
  
   
 0.847
pbp2b
Penicillin-binding protein 2B, putative; GC: 48.57%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.767. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.995); Curator(s): P. Xu; Protein involved in penicillin binding and cell wall biosynthesis (sensu Bacteria).
  
   
 0.817
ftsA
Cell division protein FtsA, putative; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
  
 
 0.795
SSA_0191
Adenine-specific DNA methylase, putative; GC: 41.82%; Codon Adaptation Index (CAI): 0.783. Curator(s): M. Serrano, J. Alves; Protein involved in transferase activity.
 
     0.777
recU
Penicillin-binding protein-like factor A/ recombinase, putative; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family.
  
   
 0.758
mecA
Adapter protein mecA, putative; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
  
     0.755
SSA_2239
Conserved uncharacterized cytosolic protein; GC: 41.67%; Codon Adaptation Index (CAI): 0.813; Belongs to the UPF0473 family.
  
     0.755
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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