STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
serBPhosphoserine phosphatase, putative; GC: 47.07%; Codon Adaptation Index (CAI): 0.765. Curator(s): L. Ozaki; Protein involved in phosphoric monoester hydrolase activity. (215 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol-phosphate synthase subunit hisF, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.954
serC
Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
  
 
 0.952
glyA
Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.922
trpB2
Tryptophan synthase beta chain, putative; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
   
 
 0.913
trpB
Tryptophan synthase beta chain, putative; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
   
 
 0.913
sdaB
L-serine dehydratase beta subunit; GC: 41.96%; Codon Adaptation Index (CAI): 0.788; Protein involved in amino acid binding; Belongs to the iron-sulfur dependent L-serine dehydratase family.
   
 
 0.907
sdaA
L-serine dehydratase alpha subunit; GC: 45.7%; Codon Adaptation Index (CAI): 0.81; Protein involved in gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family.
   
 
 0.907
ilvA
Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
 0.904
SSA_1013
Phosphatidylserine synthase, putative; GC: 49.13%; Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.783; Protein involved in transferase activity.
    
  0.903
SSA_0042
Amino acid recemase, putative; GC: 44.06%; Codon Adaptation Index (CAI): 0.766. Curator(s): J. Alves; Protein involved in aspartate racemase activity and racemase and epimerase activity, acting on amino acids and derivatives; Belongs to the aspartate/glutamate racemases family.
    
  0.901
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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