STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SSA_0917Cobalamin-independent methionine synthase II, putative; GC: 48.28%; Codon Adaptation Index (CAI): 0.765. Curator(s): T. Kitten, J. Alves; Protein involved in methionine biosynthesis. (387 aa)    
Predicted Functional Partners:
metK
S-adenosylmethionine synthetase, putative; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.815
luxS
S-ribosylhomocysteine lyase, putative; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
 
  
 0.782
metB
Cystathionine gamma-synthase, putative; GC: 45.6%; Codon Adaptation Index (CAI): 0.784; Protein involved in amino acid metabolism.
  
 
 0.726
metF
5,10-methylenetetrahydrofolate reductase, putative; GC: 45.39%; Codon Adaptation Index (CAI): 0.772. Curator(s): M. Chaplin; Protein involved in oxidoreductase activity; Belongs to the methylenetetrahydrofolate reductase family.
  
  
 0.718
cysD
O-acetylhomoserine sulfhydrylase, putative; GC: 47.07%; Codon Adaptation Index (CAI): 0.799. Curator(s): L. Ozaki; Protein involved in transferase activity, transferring alkyl or aryl (other than methyl) groups and cellodextrin phosphorylase activity.
  
 
 0.670
cpsY
Transcriptional regulator, LysR family, putative; GC: 44.55%; Codon Adaptation Index (CAI): 0.758. Helix-turn-helix prediction: LysR. Possible capsular polysaccharide biosynthesis regulator. Curator(s): J. Alves; Protein involved in regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family.
 
  
 0.550
divIC
Cell division protein DivIC, putative; GC: 38.48%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.823. Curator(s): J. Alves; Protein involved in cell cycle and cell division.
      
 0.501
SSA_0918
Conserved uncharacterized protein; GC: 44.44%; Codon Adaptation Index (CAI): 0.78. LipoP prediction: SpII. SignalP prediction: Yes (prob. 1); Curator(s): T. Kitten.
       0.495
metA
Homoserine O-succinyltransferase, putative; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
  
  
 0.443
SSA_0920
Hypothetical protein; GC: 29.17%; Codon Adaptation Index (CAI): 0.786. Curator(s): T. Kitten.
       0.438
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.