STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arsCArsenate reductase, glutaredoxin family, putative; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (133 aa)    
Predicted Functional Partners:
suhB
Inositol monophosphatase (Mg++ dependent), putative; GC: 46.69%; Codon Adaptation Index (CAI): 0.769. Curator(s): T. Kitten, J. Alves; Protein involved in inositol or phosphatidylinositol phosphatase activity.
 
     0.824
SSA_0940
NOL1/NOP2/sun family protein, putative; GC: 46.36%; Codon Adaptation Index (CAI): 0.798. Curator(s): T. Kitten; Protein involved in transferase activity.
  
    0.821
SSA_0938
Conserved hypothetical protein; GC: 40.86%; Codon Adaptation Index (CAI): 0.774. Curator(s): T. Kitten; Protein involved in molecular function unknown; Belongs to the UPF0223 family.
  
    0.809
rpoA
DNA-directed RNA polymerase, alpha chain, putative; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.806
rpoD
DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32), putative; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
    
   0.765
rpoC
DNA-directed RNA polymerase I, beta chain (160 kDa subunit), putative; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.750
SSA_0313
Conserved uncharacterized protein; GC: 41.13%; Codon Adaptation Index (CAI): 0.813. Highly conserved, but so far Firmicutes specific. Curator(s): T. Kitten, J. Alves; Belongs to the UPF0356 family.
  
 
   0.625
clpP
ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
  
 0.623
rpoE
DNA-directed RNA polymerase delta subunit, putative; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.
  
 
 0.620
recU
Penicillin-binding protein-like factor A/ recombinase, putative; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family.
  
     0.613
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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