STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
leuA2-isopropylmalate synthase, putative; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (572 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit, putative; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.999
leuD
3-isopropylmalate dehydratase small subunit, putative; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.999
leuB
3-isopropylmalate dehydrogenase, putative; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family.
 
 
 0.998
ilvN
Acetolactate synthase small subunit, putative; GC: 47.8%; Codon Adaptation Index (CAI): 0.77; Protein involved in amino acid binding.
 
 
 0.993
ilvD
Dihydroxy-acid dehydratase, putative; GC: 50.15%; Codon Adaptation Index (CAI): 0.792; Protein involved in branched chain family amino acid biosynthesis; Belongs to the IlvD/Edd family.
 
 
 0.986
ilvE
Branched-chain amino acid aminotransferase, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.788; Protein involved in transferase activity and branched chain family amino acid metabolism.
  
 0.977
accC
Biotin carboxylase, putative; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.963
ilvB
Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding.
 
 
 0.961
ilvC
Ketol-acid reductoisomerase, putative; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.918
SSA_0523
Aldehyde dehydrogenase, putative; GC: 44.9%; Codon Adaptation Index (CAI): 0.796. Curator(s): D. Akan; Protein involved in oxidoreductase activity.
  
 0.917
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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