STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dnaXDNA-directed DNA polymerase III chain, putative; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (556 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...]
 
 
 0.995
holB
DNA polymerase III, delta' subunit, putative; GC: 44.89%; Codon Adaptation Index (CAI): 0.795; Protein involved in 3'-5' exonuclease activity.
 
 
0.994
dnaE
DNA-polymerase III alpha-chain, putative; GC: 46.17%; Codon Adaptation Index (CAI): 0.784. Curator(s): L. Ozaki; Protein involved in 3'-5' exonuclease activity and nucleotidyltransferase activity.
 
 0.993
holA
Conserved hypothetical protein; GC: 41.93%; Codon Adaptation Index (CAI): 0.805. Helix-turn-helix prediction: AraC. Curator(s): X. Ge; Protein involved in DNA replication.
   
 0.992
polC
DNA polymerase III polC-type, putative; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 0.964
SSA_0996
cGMP-specific phosphodiesterase, putative; GC: 43.37%; Codon Adaptation Index (CAI): 0.808. Contains GAF domain, involved in signal transduction. Curator(s): T. Kitten, J. Alves.
  
    0.860
ssb2
Single-strand DNA-binding protein (conjugal DNA-protein transfer system), putative; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
    
 
 0.843
ssb
Single-strand binding protein, putative; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
    
 
 0.822
SSA_0998
Conserved hypothetical protein; GC: 41.15%; Codon Adaptation Index (CAI): 0.781. Curator(s): T. Kitten.
       0.790
recR
Recombinational DNA repair protein (RecF pathway), putative; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
 
  
 0.782
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: medium (64%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.