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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lspALipoprotein signal peptidase, putative; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (155 aa)    
Predicted Functional Partners:
lgt
Prolipoprotein diacylglyceryl transferase, putative; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
 
   
 0.916
SSA_1070
Ribosomal large subunit pseudouridine synthase D, putative; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
  
    0.861
SSA_1068
Transcriptional regulator, LysR family (capsular polysaccharide biosynthesis regulation), putative; GC: 44.27%; Codon Adaptation Index (CAI): 0.802. Helix-turn-helix prediction: LysR. Curator(s): J. Alves; Protein involved in regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family.
       0.800
fruA
PTS system, fructose specific II ABC components, putative; GC: 43.96%; Transporter classification TC:4.A.2.1.3. Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.786.
     
 0.720
uvrB
Helicase subunit of the DNA excision repair complex, subunit B, putative; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a [...]
      
 0.705
ruvB
Holliday junction DNA helicase ruvB, putative; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
     
 0.702
scpB
Segregation and condensation protein B, putative; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
  
  
 0.603
SSA_1067
Conserved hypothetical protein; GC: 43.25%; Codon Adaptation Index (CAI): 0.766; Protein involved in N-acetyltransferase activity and transferase activity.
       0.587
proB
Glutamate 5-kinase, putative; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
  
    0.585
recN
DNA repair and genetic recombination, putative; May be involved in recombinational repair of damaged DNA.
 
   
 0.572
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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