STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proBGlutamate 5-kinase, putative; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (369 aa)    
Predicted Functional Partners:
proA
Gamma-glutamyl phosphate reductase, putative; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 0.999
proC
Pyrroline-5-carboxylate reductase, putative; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
 
 
 0.958
lspA
Lipoprotein signal peptidase, putative; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
  
    0.585
SSA_1070
Ribosomal large subunit pseudouridine synthase D, putative; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
       0.564
SSA_1068
Transcriptional regulator, LysR family (capsular polysaccharide biosynthesis regulation), putative; GC: 44.27%; Codon Adaptation Index (CAI): 0.802. Helix-turn-helix prediction: LysR. Curator(s): J. Alves; Protein involved in regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family.
       0.562
obg
GTP-binding protein, putative; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
 
  
 0.520
comEC
Competence protein, putative; GC: 43.24%; Transporter classification TC:3.A.11.1.1. Transmembrane domains: 9. Codon Adaptation Index (CAI): 0.763. Helix-turn-helix prediction: AraC. Curator(s): X. Ge, J. Alves; Protein involved in establishment of competence for transformation.
     
 0.474
serC
Phosphoserine aminotransferase, putative; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
  
  
 0.473
SSA_1076
Conserved hypothetical protein; GC: 44.94%; Codon Adaptation Index (CAI): 0.778; Protein involved in hydrolase activity and fatty acid biosynthesis.
  
    0.463
hemN
Coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
       0.447
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.