node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSA_0433 | SSA_0434 | SSA_0433 | SSA_0434 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | 0.999 |
SSA_0433 | fhs | SSA_0433 | SSA_1200 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | 0.919 |
SSA_0433 | fhs1 | SSA_0433 | SSA_0432 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis. | 0.973 |
SSA_0433 | folD | SSA_0433 | SSA_0671 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.937 |
SSA_0433 | purH | SSA_0433 | SSA_0035 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves. | 0.903 |
SSA_0433 | purN | SSA_0433 | SSA_0033 | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | Phosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.907 |
SSA_0434 | SSA_0433 | SSA_0434 | SSA_0433 | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. | 0.999 |
SSA_0434 | dfrA | SSA_0434 | SSA_1092 | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | Dihydrofolate reductase, putative; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.900 |
SSA_0434 | fhs | SSA_0434 | SSA_1200 | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | 0.904 |
SSA_0434 | fhs1 | SSA_0434 | SSA_0432 | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis. | 0.966 |
SSA_0434 | folD | SSA_0434 | SSA_0671 | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.909 |
SSA_0434 | glyA | SSA_0434 | SSA_1155 | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
SSA_0434 | purH | SSA_0434 | SSA_0035 | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves. | 0.900 |
SSA_0434 | purN | SSA_0434 | SSA_0033 | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | Phosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
SSA_1198 | fhs | SSA_1198 | SSA_1200 | ATPase (PilT family), putative; GC: 41.83%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.809. LipoP prediction: SpII. SignalP prediction: Yes (prob. 0.774). | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | 0.800 |
dfrA | SSA_0434 | SSA_1092 | SSA_0434 | Dihydrofolate reductase, putative; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin. | 0.900 |
dfrA | fhs | SSA_1092 | SSA_1200 | Dihydrofolate reductase, putative; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family. | 0.911 |
dfrA | fhs1 | SSA_1092 | SSA_0432 | Dihydrofolate reductase, putative; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis. | 0.911 |
dfrA | glyA | SSA_1092 | SSA_1155 | Dihydrofolate reductase, putative; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
dfrA | purH | SSA_1092 | SSA_0035 | Dihydrofolate reductase, putative; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves. | 0.914 |