STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ppnKInorganic polyphosphate/ATP-NAD kinase, putative; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (282 aa)    
Predicted Functional Partners:
nadE
NH(3)-dependent NAD(+) synthetase, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.949
nadD
Nicotinate-nucleotide adenylyltransferase, putative; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
  
 
 0.937
nadR
ATPase/kinase, putative; GC: 45.33%; Codon Adaptation Index (CAI): 0.804. Possibly involved in NAD metabolism. Curator(s): J. Alves; Protein involved in nucleotidyltransferase activity and regulation of transcription.
  
 
 0.937
pta
Phosphate acetyltransferase, putative; GC: 45.6%; Codon Adaptation Index (CAI): 0.781; Protein involved in transferase activity.
     
 0.916
cobB
NAD-dependent deacetylase, putative; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily.
  
 
 0.913
SSA_1210
GTP pyrophosphokinase, putative; GC: 43.45%; Codon Adaptation Index (CAI): 0.805; Protein involved in kinase activity and guanosine tetraphosphate metabolism.
 
    0.891
SSA_1208
23S rRNA pseudouridine synthase, putative; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
  
  
 0.867
SSA_1211
Conserved hypothetical protein; GC: 40.7%; Codon Adaptation Index (CAI): 0.764; Protein involved in cAMP biosynthesis.
 
     0.792
mutY
A/G-specific adenine glycosylase, putative; Adenine glycosylase active on G-A mispairs.
       0.730
prs
Ribose-phosphate pyrophosphokinase 2, putative; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
 
   0.714
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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