STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ungUracil-DNA glycosylase, putative; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (217 aa)    
Predicted Functional Partners:
exoA
Exodeoxyribonuclease, putative; GC: 45.2%; Codon Adaptation Index (CAI): 0.754; Protein involved in DNA repair.
   
 0.853
pyrC
Dihydroorotase, putative; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
    0.810
mutX
Mutator protein, putative; GC: 46.24%; Codon Adaptation Index (CAI): 0.785; Protein involved in hydrolase activity; Belongs to the Nudix hydrolase family.
       0.800
SSA_1238
Conserved hypothetical protein; GC: 43.69%; Codon Adaptation Index (CAI): 0.806.
   
   0.721
SSA_1239
Membrane protein, putative; GC: 41.91%; Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.766.
       0.702
trpD
Anthranilate phosphoribosyltransferase, putative; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
      0.682
dnaN
DNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...]
   
 
 0.672
nth
Endonuclease III, putative; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.650
pyrE
Orotate phosphoribosyltransferase, putative; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 0.615
SSA_1234
5'-nucleotidase, putative; GC: 47.41%; Codon Adaptation Index (CAI): 0.789. LipoP prediction: SpI. SignalP prediction: Yes (prob. 1); Protein involved in hydrolase activity, acting on ester bonds.
  
    0.577
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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