STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
pyrFOrotidine-5'-phosphate decarboxylase, putative; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (230 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase, putative; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.999
pyrR
Pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
  
 
 0.994
pyrC
Dihydroorotase, putative; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.992
pyrB
Aspartate carbamoyltransferase, putative; GC: 45.75%; Codon Adaptation Index (CAI): 0.798; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.991
pyrD
Dihydroorotate dehydrogenase B, putative; Catalyzes the conversion of dihydroorotate to orotate.
 
  
 0.990
pyrK
Dihydroorotate dehydrogenase electron transfer subunit, putative; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
  
  
 0.987
carB
Carbamoyl-phosphate synthase large chain, putative; GC: 49.5%; Codon Adaptation Index (CAI): 0.783; Protein involved in metal ion binding.
  
  
 0.978
pyrP
Xanthine/uracil permeases, putative; GC: 47.74%; Transporter classification TC:2.A.40.1.2. Transmembrane domains: 11. Codon Adaptation Index (CAI): 0.767.
  
  
 0.969
carA
Carbamoyl-phosphate synthase small chain, putative; GC: 48.24%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.764; Protein involved in ligase activity; Belongs to the CarA family.
  
  
 0.964
upp
Uracil phosphoribosyltransferase, putative; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
 
 0.955
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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