STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cobBNAD-dependent deacetylase, putative; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (245 aa)    
Predicted Functional Partners:
nadR
ATPase/kinase, putative; GC: 45.33%; Codon Adaptation Index (CAI): 0.804. Possibly involved in NAD metabolism. Curator(s): J. Alves; Protein involved in nucleotidyltransferase activity and regulation of transcription.
   
 
  0.991
deoD
Purine nucleoside phosphorylase, family 1, putative; GC: 44.03%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.783; Protein involved in nucleoside metabolism.
    
 0.989
punA
Purine nucleoside phosphorylase, putative; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
 0.944
nadD
Nicotinate-nucleotide adenylyltransferase, putative; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 0.921
nadE
NH(3)-dependent NAD(+) synthetase, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
 0.915
ppnK
Inorganic polyphosphate/ATP-NAD kinase, putative; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
  
 
 0.913
SSA_2046
Uridine phosphorylase, putative; GC: 47.06%; Codon Adaptation Index (CAI): 0.772; Protein involved in nucleoside metabolism.
     
 0.904
SSA_1257
Conserved hypothetical protein; GC: 43.04%; Codon Adaptation Index (CAI): 0.748. Curator(s): J. Alves; Protein involved in kinase activity.
       0.849
hit
Diadenosine tetraphosphate (Ap4A) hydrolase; GC: 44.77%; Codon Adaptation Index (CAI): 0.802. Curator(s): J. Alves.
  
 
  0.770
polA
DNA polymerase I - 3'-5' exonuclease and polymerase domains, putative; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.583
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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