Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
aroA3-phosphoshikimate 1-carboxyvinyltransferase, putative; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)    
Predicted Functional Partners:
aroC
Chorismate synthase, putative; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.999
aroK
Shikimate kinase, putative; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
 
 0.998
tyrA
Prephenate dehydrogenase, putative; GC: 47.52%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.759; Protein involved in prephenate dehydrogenase activity.
  
 0.996
aroB
3-dehydroquinate synthase, putative; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 0.992
aroE
Shikimate dehydrogenase, putative; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
 0.982
cmk
Cytidylate kinase, putative; GC: 44.69%; Codon Adaptation Index (CAI): 0.79; Protein involved in nucleotide kinase activity.
    
 0.924
pheA
Prephenate dehydratase, putative; GC: 47.48%; Codon Adaptation Index (CAI): 0.75; Protein involved in amino acid binding.
  
  
 0.887
SSA_1460
Transcriptional attenuator LytR, putative; GC: 47.7%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.789. Capsular polysaccharide biosynthesis-related transcriptional attenuator. Curator(s): J. Alves.
       0.831
aroD
3-dehydroquinate dehydratase, putative; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family.
     
 0.788
SSA_1459
RNA methyltransferase, putative; GC: 47.78%; Codon Adaptation Index (CAI): 0.76; Protein involved in transferase activity; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
       0.722
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.