STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
coaEDephospho-CoA kinase, putative; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)    
Predicted Functional Partners:
mutM
Formamidopyrimidine-DNA glycosylase, putative; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
 
  
 0.994
kdtB
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
    
 0.963
acpS
Acyl carrier protein synthase, putative; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.
    
 0.911
polA
DNA polymerase I - 3'-5' exonuclease and polymerase domains, putative; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
  
 0.814
SSA_1608
Conserved hypothetical protein; GC: 42.68%; Codon Adaptation Index (CAI): 0.812; Protein involved in hydrolase activity; Belongs to the Nudix hydrolase family.
       0.811
tkt
Transketolase, putative; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
      
 0.759
vacB
Exoribonuclease, VacB/Rnb family, putative; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
  
  
 0.734
pmrA
Major facilitator superfamily multi-drug resistance efflux pump pmrA, putative; GC: 48.02%; Transporter classification TC:2.A.1.2.20. Transmembrane domains: 10. Codon Adaptation Index (CAI): 0.739. Helix-turn-helix prediction: AraC. Curator(s): J. Alves.
       0.728
tuf
Elongation factor Tu, putative; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
   
  
 0.698
birA
Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.693
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: medium (60%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.