STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfs5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)    
Predicted Functional Partners:
luxS
S-ribosylhomocysteine lyase, putative; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
 
 
 0.990
SSA_0378
TRZ/ATZ family hydrolase, putative; GC: 49.29%; Codon Adaptation Index (CAI): 0.772. Curator(s): T. Kitten; Protein involved in hydrolase activity.
    
 0.909
SSA_1812
Modification methylase, putative; GC: 29.83%; Codon Adaptation Index (CAI): 0.737; Protein involved in transferase activity.
    
  0.902
metB
Cystathionine gamma-synthase, putative; GC: 45.6%; Codon Adaptation Index (CAI): 0.784; Protein involved in amino acid metabolism.
  
 
 0.830
metF
5,10-methylenetetrahydrofolate reductase, putative; GC: 45.39%; Codon Adaptation Index (CAI): 0.772. Curator(s): M. Chaplin; Protein involved in oxidoreductase activity; Belongs to the methylenetetrahydrofolate reductase family.
     
 0.780
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase, putative; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
 
 0.777
SSA_1638
Conserved hypothetical protein; GC: 40.13%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.816. Curator(s): J. Alves.
       0.777
metK
S-adenosylmethionine synthetase, putative; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.773
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
   
 
 0.688
fhs
Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family.
      
 0.672
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.