STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
exoAExodeoxyribonuclease, putative; GC: 45.2%; Codon Adaptation Index (CAI): 0.754; Protein involved in DNA repair. (322 aa)    
Predicted Functional Partners:
nth
Endonuclease III, putative; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
 0.978
dnaN
DNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...]
   
 0.925
polA
DNA polymerase I - 3'-5' exonuclease and polymerase domains, putative; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.924
mutY
A/G-specific adenine glycosylase, putative; Adenine glycosylase active on G-A mispairs.
    
 0.903
ung
Uracil-DNA glycosylase, putative; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 0.853
birA
Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
    0.846
holB
DNA polymerase III, delta' subunit, putative; GC: 44.89%; Codon Adaptation Index (CAI): 0.795; Protein involved in 3'-5' exonuclease activity.
   
 0.786
SSA_1707
Conserved uncharacterized protein; GC: 43.15%; Codon Adaptation Index (CAI): 0.768; Protein involved in oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen.
  
    0.784
SSA_2059
16S rRNA uridine-516 pseudouridylate synthase, putative; GC: 48.01%; Codon Adaptation Index (CAI): 0.761. Helix-turn-helix prediction: AraC. Curator(s): J. Alves; Protein involved in pseudouridine synthase activity; Belongs to the pseudouridine synthase RsuA family.
  
    0.782
SSA_2325
3-methyladenine DNA glycosylase, putative; GC: 49.92%; Codon Adaptation Index (CAI): 0.778; Protein involved in hydrolase activity, acting on glycosyl bonds, DNA N-glycosylase activity and base-excision repair; Belongs to the DNA glycosylase MPG family.
    
 0.772
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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