STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SSA_1965Stomatin/prohibitin-like membrane protease subunits, putative; GC: 42.55%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.768. (310 aa)    
Predicted Functional Partners:
ftsH
ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
 0.924
ilvA
Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
   0.781
SSA_1964
Conserved uncharacterized protein; Staph./S.pneum; GC: 35.19%; Codon Adaptation Index (CAI): 0.839. Curator(s): J. Alves.
       0.720
SSA_1314
Fe-S-cluster oxidoreductase, putative; GC: 44.04%; Codon Adaptation Index (CAI): 0.804; Protein involved in molecular function unknown.
 
     0.691
ilvC
Ketol-acid reductoisomerase, putative; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
    0.683
SSA_2170
Conserved hypothetical protein; GC: 41.37%; Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.774. SignalP prediction: Yes (prob. 0.942).
   
 0.669
ilvN
Acetolactate synthase small subunit, putative; GC: 47.8%; Codon Adaptation Index (CAI): 0.77; Protein involved in amino acid binding.
  
    0.627
SSA_2370
Zn-dependemt peptidase (insulinase), M16 family, putative; GC: 39.04%; Codon Adaptation Index (CAI): 0.807. Curator(s): J. Alves.
  
 0.588
SSA_2371
Zn-dependent peptidase, putative; GC: 38.25%; Codon Adaptation Index (CAI): 0.816. Curator(s): J. Alves; Protein involved in peptidase activity.
  
 0.588
hflX
HflX GTPase, putative; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
 
  
 0.583
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.