| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aldB | ilvB | SSA_0901 | SSA_1970 | Alpha-acetolactate decarboxylase, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.808. Curator(s): L. Ozaki; Protein involved in acetolactate decarboxylase activity; Belongs to the alpha-acetolactate decarboxylase family. | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | 0.971 |
| aldB | ilvN | SSA_0901 | SSA_1969 | Alpha-acetolactate decarboxylase, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.808. Curator(s): L. Ozaki; Protein involved in acetolactate decarboxylase activity; Belongs to the alpha-acetolactate decarboxylase family. | Acetolactate synthase small subunit, putative; GC: 47.8%; Codon Adaptation Index (CAI): 0.77; Protein involved in amino acid binding. | 0.910 |
| aldB | spxB | SSA_0901 | SSA_0391 | Alpha-acetolactate decarboxylase, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.808. Curator(s): L. Ozaki; Protein involved in acetolactate decarboxylase activity; Belongs to the alpha-acetolactate decarboxylase family. | Pyruvate oxidase, putative; GC: 43.3%; Codon Adaptation Index (CAI): 0.777. Curator(s): T. Kitten; Protein involved in thiamin pyrophosphate binding; Belongs to the TPP enzyme family. | 0.730 |
| ilvA | ilvB | SSA_1967 | SSA_1970 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | 0.978 |
| ilvA | ilvC | SSA_1967 | SSA_1968 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Ketol-acid reductoisomerase, putative; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.966 |
| ilvA | ilvD | SSA_1967 | SSA_2286 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Dihydroxy-acid dehydratase, putative; GC: 50.15%; Codon Adaptation Index (CAI): 0.792; Protein involved in branched chain family amino acid biosynthesis; Belongs to the IlvD/Edd family. | 0.932 |
| ilvA | ilvN | SSA_1967 | SSA_1969 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase small subunit, putative; GC: 47.8%; Codon Adaptation Index (CAI): 0.77; Protein involved in amino acid binding. | 0.986 |
| ilvA | leuA | SSA_1967 | SSA_0975 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 2-isopropylmalate synthase, putative; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.630 |
| ilvA | leuB | SSA_1967 | SSA_0977 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydrogenase, putative; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.968 |
| ilvA | leuC | SSA_1967 | SSA_0980 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydratase large subunit, putative; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.551 |
| ilvA | leuD | SSA_1967 | SSA_0981 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydratase small subunit, putative; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.626 |
| ilvA | spxB | SSA_1967 | SSA_0391 | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Pyruvate oxidase, putative; GC: 43.3%; Codon Adaptation Index (CAI): 0.777. Curator(s): T. Kitten; Protein involved in thiamin pyrophosphate binding; Belongs to the TPP enzyme family. | 0.549 |
| ilvB | aldB | SSA_1970 | SSA_0901 | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | Alpha-acetolactate decarboxylase, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.808. Curator(s): L. Ozaki; Protein involved in acetolactate decarboxylase activity; Belongs to the alpha-acetolactate decarboxylase family. | 0.971 |
| ilvB | ilvA | SSA_1970 | SSA_1967 | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | Threonine desaminase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.978 |
| ilvB | ilvC | SSA_1970 | SSA_1968 | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | Ketol-acid reductoisomerase, putative; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.997 |
| ilvB | ilvD | SSA_1970 | SSA_2286 | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | Dihydroxy-acid dehydratase, putative; GC: 50.15%; Codon Adaptation Index (CAI): 0.792; Protein involved in branched chain family amino acid biosynthesis; Belongs to the IlvD/Edd family. | 0.979 |
| ilvB | ilvN | SSA_1970 | SSA_1969 | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | Acetolactate synthase small subunit, putative; GC: 47.8%; Codon Adaptation Index (CAI): 0.77; Protein involved in amino acid binding. | 0.999 |
| ilvB | leuA | SSA_1970 | SSA_0975 | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | 2-isopropylmalate synthase, putative; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.961 |
| ilvB | leuB | SSA_1970 | SSA_0977 | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | 3-isopropylmalate dehydrogenase, putative; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.974 |
| ilvB | leuC | SSA_1970 | SSA_0980 | Acetolactate synthase, large subunit, biosynthetic type, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.799; Protein involved in thiamin pyrophosphate binding. | 3-isopropylmalate dehydratase large subunit, putative; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.617 |
