STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
thiDHydroxymethylpyrimidine/phosphomethylpyrimidine kinase, putative; GC: 46.04%; Codon Adaptation Index (CAI): 0.765; Protein involved in phosphomethylpyrimidine kinase activity and kinase activity. (256 aa)    
Predicted Functional Partners:
truA
tRNA pseudouridine synthase A, putative; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
    0.929
pdxK
Pyridoxal kinase, putative; GC: 44.64%; Codon Adaptation Index (CAI): 0.746; Protein involved in transferase activity and kinase activity.
   
 
 0.907
SSA_2000
Conserved hypothetical protein; GC: 44.72%; Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.758. SignalP prediction: Yes (prob. 0.865).
     
 0.902
SSA_1999
Conserved hypothetical protein; GC: 48.4%; Codon Adaptation Index (CAI): 0.774; Protein involved in molecular function unknown; Belongs to the UPF0340 family.
       0.846
ropA
Trigger factor, putative; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
       0.737
folK
Bifunctional folate synthesis protein, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
  
 0.619
dnaJ
Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...]
   
 
 0.612
mesJ
Cell cycle control ATPase, PP-loop superfamily, putative; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
  
  
 0.553
guaA
GMP synthase [glutamine-hydrolyzing], putative; Catalyzes the synthesis of GMP from XMP.
     
 0.538
birA
Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.507
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.