| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SSA_2012 | SSA_2013 | SSA_2012 | SSA_2013 | Conserved hypothetical protein; GC: 39.79%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.781. Curator(s): T. Kitten, J. Alves. | Conserved hypothetical protein; GC: 41.98%; Codon Adaptation Index (CAI): 0.779. | 0.965 |
| SSA_2012 | grpE | SSA_2012 | SSA_2008 | Conserved hypothetical protein; GC: 39.79%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.781. Curator(s): T. Kitten, J. Alves. | Molecular chaperone GrpE (HSP-70 cofactor), putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.612 |
| SSA_2012 | hrcA | SSA_2012 | SSA_2009 | Conserved hypothetical protein; GC: 39.79%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.781. Curator(s): T. Kitten, J. Alves. | Heat shock transcription repressor HrcA, putative; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.653 |
| SSA_2013 | SSA_2012 | SSA_2013 | SSA_2012 | Conserved hypothetical protein; GC: 41.98%; Codon Adaptation Index (CAI): 0.779. | Conserved hypothetical protein; GC: 39.79%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.781. Curator(s): T. Kitten, J. Alves. | 0.965 |
| SSA_2013 | grpE | SSA_2013 | SSA_2008 | Conserved hypothetical protein; GC: 41.98%; Codon Adaptation Index (CAI): 0.779. | Molecular chaperone GrpE (HSP-70 cofactor), putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.571 |
| SSA_2013 | hrcA | SSA_2013 | SSA_2009 | Conserved hypothetical protein; GC: 41.98%; Codon Adaptation Index (CAI): 0.779. | Heat shock transcription repressor HrcA, putative; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.610 |
| birA | dnaK | SSA_0999 | SSA_2007 | Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Chaperone protein dnaK/HSP70, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.466 |
| birA | groS | SSA_0999 | SSA_0225 | Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.743 |
| birA | hrcA | SSA_0999 | SSA_2009 | Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Heat shock transcription repressor HrcA, putative; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.642 |
| ctsR | dnaJ | SSA_2200 | SSA_2005 | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.472 |
| ctsR | dnaK | SSA_2200 | SSA_2007 | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | Chaperone protein dnaK/HSP70, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.604 |
| ctsR | groEL | SSA_2200 | SSA_0226 | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.648 |
| ctsR | groS | SSA_2200 | SSA_0225 | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.835 |
| ctsR | grpE | SSA_2200 | SSA_2008 | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | Molecular chaperone GrpE (HSP-70 cofactor), putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.641 |
| ctsR | hrcA | SSA_2200 | SSA_2009 | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | Heat shock transcription repressor HrcA, putative; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.695 |
| dnaJ | ctsR | SSA_2005 | SSA_2200 | Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | 0.472 |
| dnaJ | dnaK | SSA_2005 | SSA_2007 | Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | Chaperone protein dnaK/HSP70, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
| dnaJ | groEL | SSA_2005 | SSA_0226 | Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.948 |
| dnaJ | groS | SSA_2005 | SSA_0225 | Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.887 |
| dnaJ | grpE | SSA_2005 | SSA_2008 | Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | Molecular chaperone GrpE (HSP-70 cofactor), putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.995 |
