Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SSA_2011ABC-type multidrug transport system, ATPase component, putative; GC: 42.86%; Transporter classification TC:3.A.1.124.1. Codon Adaptation Index (CAI): 0.811. Curator(s): J. Alves; Protein involved in ATPase activity and nucleoside-triphosphatase activity. (279 aa)    
Predicted Functional Partners:
SSA_2010
ABC-type multidrug transport system, permease component, putative; GC: 37.86%; Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.8. Curator(s): J. Alves.
 
    0.954
SSA_2013
Conserved hypothetical protein; GC: 41.98%; Codon Adaptation Index (CAI): 0.779.
  
    0.690
SSA_2012
Conserved hypothetical protein; GC: 39.79%; Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.781. Curator(s): T. Kitten, J. Alves.
       0.642
hrcA
Heat shock transcription repressor HrcA, putative; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
       0.472
SSA_0762
Conserved hypothetical protein; GC: 36.34%; Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.754. SignalP prediction: Yes (prob. 0.813); Curator(s): X. Ge.
       0.450
SSA_0761
Transcriptional regulator, XRE family, putative; GC: 48.36%; Codon Adaptation Index (CAI): 0.695. Curator(s): X. Ge, J. Alves; Protein involved in DNA binding.
       0.448
SSA_1766
Bacitracin ABC transporter, permease protein, putative; GC: 36.42%; Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.748; Protein involved in response to antibiotic.
  
 
 0.431
grpE
Molecular chaperone GrpE (HSP-70 cofactor), putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...]
   
   0.430
cysS
Cysteinyl-tRNA synthetase, putative; GC: 48.44%; Codon Adaptation Index (CAI): 0.776; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
     0.406
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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