Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SSA_2045Reductase, putative; GC: 46.17%; Codon Adaptation Index (CAI): 0.722; Protein involved in NADP binding. (173 aa)    
Predicted Functional Partners:
cysS
Cysteinyl-tRNA synthetase, putative; GC: 48.44%; Codon Adaptation Index (CAI): 0.776; Belongs to the class-I aminoacyl-tRNA synthetase family.
     
 0.845
mrnC
Conserved hypothetical protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family.
       0.834
lrp
Leucine-rich protein, putative; GC: 44.52%; Codon Adaptation Index (CAI): 0.762. Helix-turn-helix prediction: AraC; Protein involved in regulation of transcription, DNA-dependent.
       0.817
SSA_2046
Uridine phosphorylase, putative; GC: 47.06%; Codon Adaptation Index (CAI): 0.772; Protein involved in nucleoside metabolism.
       0.801
cysE
Serine acetyltransferase, putative; GC: 53.72%; Codon Adaptation Index (CAI): 0.747; Protein involved in serine O-acetyltransferase activity and transferase activity.
       0.780
SSA_2047
Hypothetical protein; GC: 49.32%; Codon Adaptation Index (CAI): 0.805.
       0.756
thyA
Thymidylate synthase, putative; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.724
clpX
ATP-dependent Clp protease ATP-binding subunit clpX, putative; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 
 0.597
folK
Bifunctional folate synthesis protein, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
     
 0.574
pnpA
Polyribonucleotide nucleotidyltransferase, putative; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
       0.560
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.