Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yajCPreprotein translocase subunit YajC, putative; GC: 45.24%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.814. LipoP prediction: SpI. Curator(s): J. Alves. (111 aa)    
Predicted Functional Partners:
secE
Preprotein translocase secE component, putative; GC: 32.22%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.783. Curator(s): J. Alves; Belongs to the SecE/SEC61-gamma family.
   
  
 0.733
secG
Protein-export membrane protein secG, putative; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.
 
  
 0.729
ropA
Trigger factor, putative; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
  
  
 0.709
tkt
Transketolase, putative; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
    0.705
uppS
Undecaprenyl pyrophosphate synthetase, putative; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
       0.671
cdsA
Phosphatidate cytidylyltransferase, putative; GC: 46.77%; Transmembrane domains: 7. Codon Adaptation Index (CAI): 0.785. SignalP prediction: Yes (prob. 0.672); Protein involved in nucleotidyltransferase activity; Belongs to the CDS family.
       0.659
tgt
Queuine tRNA-ribosyltransferase, putative; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose [...]
  
  
 0.651
yidC-2
Membrane protein (preprotein translocase) oxaA 1 precursor, putative; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
 
  
 0.648
rpoE
DNA-directed RNA polymerase delta subunit, putative; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.
  
    0.645
proS
Prolyl-tRNA synthetase, putative; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and in [...]
  
  
 0.642
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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