STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
radAATP-dependent serine protease, putative; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (397 aa)    
Predicted Functional Partners:
recA
RecA protein, putative; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
  
 0.865
dut
Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
     
 0.856
recX
Conserved hypothetical protein; Modulates RecA activity; Belongs to the RecX family.
  
  
 0.809
polA
DNA polymerase I - 3'-5' exonuclease and polymerase domains, putative; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.740
tarI
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2, putative; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
 
  
 0.728
pcrA
ATP-dependent DNA helicase, putative; GC: 48.01%; Codon Adaptation Index (CAI): 0.775. Curator(s): L. Ozaki; Protein involved in DNA repair.
  
  
 0.660
SSA_2159
Conserved hypothetical protein; GC: 47.09%; Codon Adaptation Index (CAI): 0.774.
       0.639
recJ
Single-stranded DNA-specific exonuclease, 5'-3', putative; GC: 46.24%; Codon Adaptation Index (CAI): 0.791. Helix-turn-helix prediction: AraC; Protein involved in 5'-3' exonuclease activity.
 
  
 0.637
radC
DNA repair protein radC, putative; GC: 41.96%; Codon Adaptation Index (CAI): 0.763; Protein involved in response to DNA damage stimulus; Belongs to the UPF0758 family.
 
   
 0.612
SSA_2156
Conserved uncharacterized protein; GC: 44.35%; Codon Adaptation Index (CAI): 0.76. Curator(s): J. Alves.
       0.581
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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