| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SSA_1311 | comEB | SSA_1311 | SSA_1497 | Hydrolase, haloacid dehalogenase-like family, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.773; Protein involved in hydrolase activity and metal ion binding. | DCMP deaminase, putative; GC: 48.08%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | 0.908 |
| SSA_1311 | dut | SSA_1311 | SSA_2160 | Hydrolase, haloacid dehalogenase-like family, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.773; Protein involved in hydrolase activity and metal ion binding. | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.901 |
| SSA_1311 | tdk | SSA_1311 | SSA_1151 | Hydrolase, haloacid dehalogenase-like family, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.773; Protein involved in hydrolase activity and metal ion binding. | Thymidine kinase, putative; GC: 43.8%; Codon Adaptation Index (CAI): 0.819. | 0.903 |
| SSA_1311 | thyA | SSA_1311 | SSA_1091 | Hydrolase, haloacid dehalogenase-like family, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.773; Protein involved in hydrolase activity and metal ion binding. | Thymidylate synthase, putative; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
| SSA_1311 | tmk | SSA_1311 | SSA_1722 | Hydrolase, haloacid dehalogenase-like family, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.773; Protein involved in hydrolase activity and metal ion binding. | Thymidylate kinase, putative; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.902 |
| SSA_1783 | dut | SSA_1783 | SSA_2160 | Xanthosine triphosphate pyrophosphatase (NTPase/HAM1 family), putative; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.940 |
| SSA_2159 | dut | SSA_2159 | SSA_2160 | Conserved hypothetical protein; GC: 47.09%; Codon Adaptation Index (CAI): 0.774. | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.855 |
| SSA_2159 | radA | SSA_2159 | SSA_2157 | Conserved hypothetical protein; GC: 47.09%; Codon Adaptation Index (CAI): 0.774. | ATP-dependent serine protease, putative; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.639 |
| comEB | SSA_1311 | SSA_1497 | SSA_1311 | DCMP deaminase, putative; GC: 48.08%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | Hydrolase, haloacid dehalogenase-like family, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.773; Protein involved in hydrolase activity and metal ion binding. | 0.908 |
| comEB | dut | SSA_1497 | SSA_2160 | DCMP deaminase, putative; GC: 48.08%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.929 |
| comEB | tdk | SSA_1497 | SSA_1151 | DCMP deaminase, putative; GC: 48.08%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | Thymidine kinase, putative; GC: 43.8%; Codon Adaptation Index (CAI): 0.819. | 0.921 |
| comEB | thyA | SSA_1497 | SSA_1091 | DCMP deaminase, putative; GC: 48.08%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | Thymidylate synthase, putative; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.925 |
| comEB | tmk | SSA_1497 | SSA_1722 | DCMP deaminase, putative; GC: 48.08%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | Thymidylate kinase, putative; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.914 |
| dnaN | dut | SSA_0002 | SSA_2160 | DNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...] | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.694 |
| dnaN | thyA | SSA_0002 | SSA_1091 | DNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...] | Thymidylate synthase, putative; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.676 |
| dut | SSA_1311 | SSA_2160 | SSA_1311 | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Hydrolase, haloacid dehalogenase-like family, putative; GC: 45.83%; Codon Adaptation Index (CAI): 0.773; Protein involved in hydrolase activity and metal ion binding. | 0.901 |
| dut | SSA_1783 | SSA_2160 | SSA_1783 | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Xanthosine triphosphate pyrophosphatase (NTPase/HAM1 family), putative; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.940 |
| dut | SSA_2159 | SSA_2160 | SSA_2159 | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Conserved hypothetical protein; GC: 47.09%; Codon Adaptation Index (CAI): 0.774. | 0.855 |
| dut | comEB | SSA_2160 | SSA_1497 | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | DCMP deaminase, putative; GC: 48.08%; Codon Adaptation Index (CAI): 0.761; Protein involved in hydrolase activity. | 0.929 |
| dut | dnaN | SSA_2160 | SSA_0002 | Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | DNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...] | 0.694 |
