STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gshABGlutathione biosynthesis bifunctional protein gshAB (Gamma-GCS-GS) (GCS-GS), putative; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily. (751 aa)    
Predicted Functional Partners:
pepN
Aminopeptidase N, putative; GC: 45.38%; Codon Adaptation Index (CAI): 0.804. Curator(s): T. Kitten.
   
 
 0.910
ilvE
Branched-chain amino acid aminotransferase, putative; GC: 46.27%; Codon Adaptation Index (CAI): 0.788; Protein involved in transferase activity and branched chain family amino acid metabolism.
   
 
 0.908
cysK
Cysteine synthase, putative; GC: 47.42%; Codon Adaptation Index (CAI): 0.797; Protein involved in lyase activity and cysteine biosynthesis; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.894
glnA
Glutamine synthetase type 1, putative; GC: 45.06%; Codon Adaptation Index (CAI): 0.803. Curator(s): T. Kitten; Protein involved in ligase activity; Belongs to the glutamine synthetase family.
    
 0.890
gdhA
NADP-specific glutamate dehydrogenase, putative; GC: 45.88%; Codon Adaptation Index (CAI): 0.789. Curator(s): T. Kitten; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
 0.858
gor
Glutathione reductase, putative; GC: 45.01%; Codon Adaptation Index (CAI): 0.79; Protein involved in FAD binding.
  
   
 0.809
SSA_0042
Amino acid recemase, putative; GC: 44.06%; Codon Adaptation Index (CAI): 0.766. Curator(s): J. Alves; Protein involved in aspartate racemase activity and racemase and epimerase activity, acting on amino acids and derivatives; Belongs to the aspartate/glutamate racemases family.
     
  0.800
SSA_1736
L-cysteine desulfhydrase, putative; GC: 45.5%; Codon Adaptation Index (CAI): 0.794; Protein involved in 1-aminocyclopropane-1-carboxylate synthase activity.
     
  0.800
topA
DNA topoisomerase I, putative; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...]
  
  
 0.701
SSA_2187
Conserved hypothetical membrane associated protein; GC: 42.67%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.761.
       0.669
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.