STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ctsRFirmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. (154 aa)    
Predicted Functional Partners:
clpC
ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family.
  
  
 0.952
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
  
 0.835
clpP
ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
  
 0.698
hrcA
Heat shock transcription repressor HrcA, putative; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.695
clpE
ATP dependent protease, putative; GC: 49.01%; Codon Adaptation Index (CAI): 0.786. Helix-turn-helix prediction: AraC. Curator(s): P. Xu; Protein involved in nucleoside-triphosphatase activity and unfolded protein binding; Belongs to the ClpA/ClpB family.
  
  
 0.683
groEL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
  
  
 0.648
grpE
Molecular chaperone GrpE (HSP-70 cofactor), putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...]
   
  
 0.641
clpL
ATP-dependent protease, ATP-binding subunit, putative; GC: 47.36%; Codon Adaptation Index (CAI): 0.799; Protein involved in nucleoside-triphosphatase activity; Belongs to the ClpA/ClpB family.
  
  
 0.631
dnaK
Chaperone protein dnaK/HSP70, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
  
 0.604
SSA_1136
ATPases with chaperone activity, ATP-binding subunit, putative; GC: 44.83%; Codon Adaptation Index (CAI): 0.774; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family.
  
  
 0.603
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.