Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cpsATranscriptional attenuator LytR, putative; GC: 43.61%; Transmembrane domains: 3. Codon Adaptation Index (CAI): 0.774. SignalP prediction: Yes (prob. 0.997). Capsular polysaccharide biosynthesis transcriptional attenuator. Curator(s): J. Alves; Protein involved in DNA replication. (502 aa)    
Predicted Functional Partners:
SSA_1460
Transcriptional attenuator LytR, putative; GC: 47.7%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.789. Capsular polysaccharide biosynthesis-related transcriptional attenuator. Curator(s): J. Alves.
  
  
  0.953
SSA_1909
Transcriptional attenuator LytR, putative; GC: 44.71%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.813. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.997). Capsular polysaccharide biosynthesis transcriptional attenuator. Curator(s): J. Alves.
  
  
 
0.927
SSA_2223
Capsular polysaccharide biosynthesis protein Wzd (chain length regulator), putative; GC: 46.12%; Transporter classification TC:8.A.3.2.1. Transmembrane domains: 2. Codon Adaptation Index (CAI): 0.787. Curator(s): J. Alves.
 
  
 0.908
dltD
D-alanine transfer protein, putative; GC: 47.83%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.775. SignalP prediction: Yes (prob. 0.453); Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid.
     
  0.900
dltC
D-alanyl carrier protein, putative; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
     
  0.900
dltB
Integral membrane protein, putative; Could be involved in the transport of activated D-alanine through the membrane.
     
 0.900
dltA
D-alanine--D-alanyl carrier protein ligase, putative; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs [...]
     
 0.900
SSA_2224
Phosphotyrosine-protein phosphatase, putative; GC: 44.81%; Codon Adaptation Index (CAI): 0.774; Protein involved in hydrolase activity.
 
  
 0.886
SSA_2222
Tyrosine-protein kinase Wze, putative; GC: 45.06%; Transporter classification TC:8.A.3.2.2. Codon Adaptation Index (CAI): 0.757. Curator(s): J. Alves; Protein involved in capsule polysaccharide biosynthesis.
  
  
 0.859
capD
Cps9E, putative; GC: 42.48%; Transmembrane domains: 3. Codon Adaptation Index (CAI): 0.757; Protein involved in biosynthesis.
 
   
 0.736
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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