Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
nrdDRibonucleotide reductase, class III, anaerobic, putative; GC: 48.63%; Codon Adaptation Index (CAI): 0.764; Protein involved in ribonucleoside-triphosphate reductase activity and metabolism. (731 aa)    
Predicted Functional Partners:
nrdG
Organic radical activating chaperone, putative; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
 
 
 0.993
pyrG
CTP synthase, putative; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
     
 0.916
dut
Deoxyuridinetriphosphatase, putative; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
    
 0.914
relA
GTP pyrophosphokinase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.909
SSA_1210
GTP pyrophosphokinase, putative; GC: 43.45%; Codon Adaptation Index (CAI): 0.805; Protein involved in kinase activity and guanosine tetraphosphate metabolism.
     
  0.900
SSA_1795
Guanosine 3',5'-bis-pyrophosphate (ppGpp) synthetase, putative; GC: 46.38%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in guanosine tetraphosphate metabolism.
     
  0.900
folE
GTP cyclohydrolase I, putative; GC: 49.37%; Codon Adaptation Index (CAI): 0.761. Helix-turn-helix prediction: AraC. Curator(s): M. Serrano; Protein involved in hydrolase activity.
     
  0.800
SSA_2229
Conserved hypothetical protein; GC: 40.8%; Codon Adaptation Index (CAI): 0.789.
       0.773
SSA_2227
Acetyl transferase, putative; GC: 46.7%; Codon Adaptation Index (CAI): 0.758; Protein involved in N-acetyltransferase activity and transferase activity.
       0.669
SSA_2228
Acetyltransferase (GNAT) family, putative; GC: 49.4%; Codon Adaptation Index (CAI): 0.741. Curator(s): J. Alves; Protein involved in N-acetyltransferase activity and transferase activity.
       0.669
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.