Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Score
SSA_2237Dihydrofolate:folylpolyglutamate synthetase, putative; GC: 48.66%; Codon Adaptation Index (CAI): 0.763; Belongs to the folylpolyglutamate synthase family. (410 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase, putative; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.995
dfrA
Dihydrofolate reductase, putative; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.931
SSA_0198
Dihydrofolate synthetase, putative; GC: 48.24%; Codon Adaptation Index (CAI): 0.749. Curator(s): M. Serrano; Belongs to the folylpolyglutamate synthase family.
  
  
 
0.914
folK
Bifunctional folate synthesis protein, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
 0.861
thyA
Thymidylate synthase, putative; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.820
folE
GTP cyclohydrolase I, putative; GC: 49.37%; Codon Adaptation Index (CAI): 0.761. Helix-turn-helix prediction: AraC. Curator(s): M. Serrano; Protein involved in hydrolase activity.
  
  
 0.716
SSA_2235
Conserved uncharacterized protein; GC: 48.75%; Codon Adaptation Index (CAI): 0.798. LipoP prediction: SpII. SignalP prediction: Yes (prob. 1).
       0.655
glyA
Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.596
guaA
GMP synthase [glutamine-hydrolyzing], putative; Catalyzes the synthesis of GMP from XMP.
 
  
 0.595
fhs1
Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis.
  
 
 0.559
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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