Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nrdIRibonucleotide reductase (NrdI family protein), putative; GC: 43.56%; Codon Adaptation Index (CAI): 0.824. Curator(s): J. Alves; Belongs to the NrdI family. (162 aa)    
Predicted Functional Partners:
nrdF
Ribonucleoside-diphosphate reductase 2, beta subunit, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
 
 
 0.996
nrdE
Ribonucleoside-diphosphate reductase, putative; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
  
 0.981
nrdH
Glutaredoxin-like protein, putative; GC: 39.27%; Codon Adaptation Index (CAI): 0.804. Involved in electron transport system for ribonucleotide reductase system NrdEF. Curator(s): X. Ge; Protein involved in cell redox homeostasis.
 
  
 0.980
SSA_2264
Conserved hypothetical protein; GC: 39.69%; Transmembrane domains: 4. Codon Adaptation Index (CAI): 0.711. LipoP prediction: SpI. SignalP prediction: Yes (prob. 0.967); Curator(s): T. Kitten.
       0.759
nrdG
Organic radical activating chaperone, putative; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
     
 0.525
nrdD
Ribonucleotide reductase, class III, anaerobic, putative; GC: 48.63%; Codon Adaptation Index (CAI): 0.764; Protein involved in ribonucleoside-triphosphate reductase activity and metabolism.
     
 0.513
relA
GTP pyrophosphokinase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.502
SSA_0102
Kinase, putative; GC: 46.78%; Codon Adaptation Index (CAI): 0.758. Curator(s): M. Serrano; Protein involved in kinase activity.
       0.450
dtd
D-tyrosyl-tRNA(Tyr) deacylase, putative; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the [...]
       0.450
SSA_1021
Conserved uncharacterized protein; GC: 47.18%; Codon Adaptation Index (CAI): 0.778.
       0.450
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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