STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SSA_2294Conserved hypothetical protein; GC: 38.45%; Codon Adaptation Index (CAI): 0.745; Protein involved in DNA replication. (201 aa)    
Predicted Functional Partners:
carA
Carbamoyl-phosphate synthase small chain, putative; GC: 48.24%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.764; Protein involved in ligase activity; Belongs to the CarA family.
  
 
 0.938
guaA
GMP synthase [glutamine-hydrolyzing], putative; Catalyzes the synthesis of GMP from XMP.
  
  
 0.756
pyrE
Orotate phosphoribosyltransferase, putative; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.733
pyrB
Aspartate carbamoyltransferase, putative; GC: 45.75%; Codon Adaptation Index (CAI): 0.798; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.704
pyrF
Orotidine-5'-phosphate decarboxylase, putative; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.703
pyrK
Dihydroorotate dehydrogenase electron transfer subunit, putative; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
  
  
 0.700
SSA_2292
DNA segregation ATPase FtsK/SpoIIIE-like protein, putative; GC: 40.24%; Codon Adaptation Index (CAI): 0.745. Helix-turn-helix prediction: AraC. Curator(s): J. Alves.
     
 0.688
pyrC
Dihydroorotase, putative; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
 
 0.687
SSA_2293
Conserved hypothetical protein; GC: 37.95%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.711. SignalP prediction: Yes (prob. 0.497); Helix-turn-helix prediction: AraC.
       0.676
pyrR
Pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
  
  
 0.664
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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