| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PNK_1166 | sdaA | PNK_1166 | PNK_1237 | Hypothetical protein. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.800 |
| PNK_1236 | pfkA | PNK_1236 | PNK_1235 | Conserved hypothetical protein; Hydrolases of the alpha/beta superfamily. | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. | 0.812 |
| PNK_1236 | sdaA | PNK_1236 | PNK_1237 | Conserved hypothetical protein; Hydrolases of the alpha/beta superfamily. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.510 |
| PNK_1552 | glyA | PNK_1552 | PNK_1921 | Putative phosphoglycerate mutase protein; Belongs to the phosphoglycerate mutase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.907 |
| PNK_1552 | pssA | PNK_1552 | PNK_0582 | Putative phosphoglycerate mutase protein; Belongs to the phosphoglycerate mutase family. | Putative CDP-diacylglycerol--serine O-phosphatidyltransferase PssA; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| PNK_1552 | sdaA | PNK_1552 | PNK_1237 | Putative phosphoglycerate mutase protein; Belongs to the phosphoglycerate mutase family. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.901 |
| aroA | glyA | PNK_1233 | PNK_1921 | Putative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the EPSP synthase family. Belongs to the type-I 3-dehydroquinase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.664 |
| aroA | pfkA | PNK_1233 | PNK_1235 | Putative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the EPSP synthase family. Belongs to the type-I 3-dehydroquinase family. | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. | 0.747 |
| aroA | sdaA | PNK_1233 | PNK_1237 | Putative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the EPSP synthase family. Belongs to the type-I 3-dehydroquinase family. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.630 |
| gcvT | glyA | PNK_2034 | PNK_1921 | Aminomethyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
| gcvT | sdaA | PNK_2034 | PNK_1237 | Aminomethyltransferase. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.431 |
| glyA | PNK_1552 | PNK_1921 | PNK_1552 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative phosphoglycerate mutase protein; Belongs to the phosphoglycerate mutase family. | 0.907 |
| glyA | aroA | PNK_1921 | PNK_1233 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the EPSP synthase family. Belongs to the type-I 3-dehydroquinase family. | 0.664 |
| glyA | gcvT | PNK_1921 | PNK_2034 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminomethyltransferase. | 0.997 |
| glyA | pssA | PNK_1921 | PNK_0582 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative CDP-diacylglycerol--serine O-phosphatidyltransferase PssA; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| glyA | sdaA | PNK_1921 | PNK_1237 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.954 |
| metB | metC | PNK_0966 | PNK_0515 | Cystathionine gamma-synthase/cystathionine beta-lysase family protein. | Cystathionine beta-lyase. | 0.905 |
| metB | sdaA | PNK_0966 | PNK_1237 | Cystathionine gamma-synthase/cystathionine beta-lysase family protein. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.823 |
| metC | metB | PNK_0515 | PNK_0966 | Cystathionine beta-lyase. | Cystathionine gamma-synthase/cystathionine beta-lysase family protein. | 0.905 |
| metC | sdaA | PNK_0515 | PNK_1237 | Cystathionine beta-lyase. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.823 |
