STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdaAL-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (463 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.954
PNK_1552
Putative phosphoglycerate mutase protein; Belongs to the phosphoglycerate mutase family.
    
  0.901
pssA
Putative CDP-diacylglycerol--serine O-phosphatidyltransferase PssA; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
     
  0.900
metC
Cystathionine beta-lyase.
   
 
 0.820
metB
Cystathionine gamma-synthase/cystathionine beta-lysase family protein.
   
 
 0.820
PNK_1166
Hypothetical protein.
     
  0.800
pfkA
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
     
 0.584
PNK_1236
Conserved hypothetical protein; Hydrolases of the alpha/beta superfamily.
  
    0.553
putA
Bifunctional protein (proline dehydrogenase and delta-1-pyrroline-5-carboxylate dehydrogenase); Belongs to the aldehyde dehydrogenase family.
  
  
 0.552
gcvPB
Putative glycine dehydrogenase (decarboxylating) subunit 2.
  
  
 0.457
Your Current Organism:
Protochlamydia naegleriophila
NCBI taxonomy Id: 389348
Other names: C. Protochlamydia naegleriophila, Candidatus Protochlamydia naegleriophila, strain KNic
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