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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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folC2Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (445 aa)    
Predicted Functional Partners:
folKE
2-Amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase / GTP cyclohydrolase I.
  
 0.999
folP
Dihydropteroate synthase.
 
 0.999
folB
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.998
Ldb0250
Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms.
 
  
 0.957
folA
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
    
 0.947
folC1
Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
  
  
0.926
thyA
D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.824
fhs
Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.
  
 
 0.597
Ldb0245
Conserved hypothetical protein (fragment); Similar to ISL5 transposase, part of ISL4-5.
     
 0.572
folD
Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
   
 0.527
Your Current Organism:
Lactobacillus delbrueckii
NCBI taxonomy Id: 390333
Other names: L. delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002, Lactobacillus delbrueckii subsp. bulgaricus DSM 20081
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