| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ldb1354 | mecA | Ldb1354 | Ldb0579 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Negative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | 0.497 |
| Ldb1354 | recU | Ldb1354 | Ldb1013 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Recombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. | 0.762 |
| Ldb1354 | spx | Ldb1354 | Ldb0578 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Conserved hypothetical protein (ArsC family); Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. | 0.490 |
| clpP | clpX | Ldb0624 | Ldb0778 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.999 |
| clpP | mecA | Ldb0624 | Ldb0579 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Negative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | 0.705 |
| clpP | spx | Ldb0624 | Ldb0578 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Conserved hypothetical protein (ArsC family); Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. | 0.599 |
| clpP | trxA1 | Ldb0624 | Ldb1602 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Thioredoxin; Belongs to the thioredoxin family. | 0.484 |
| clpP | trxB1 | Ldb0624 | Ldb0613 | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Thioredoxin reductase. | 0.495 |
| clpX | clpP | Ldb0778 | Ldb0624 | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.999 |
| clpX | coiA | Ldb0778 | Ldb0582 | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Putative competence protein CoiA (fragment). | 0.409 |
| clpX | mecA | Ldb0778 | Ldb0579 | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Negative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | 0.417 |
| clpX | spx | Ldb0778 | Ldb0578 | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Conserved hypothetical protein (ArsC family); Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. | 0.612 |
| clpX | trxA1 | Ldb0778 | Ldb1602 | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Thioredoxin; Belongs to the thioredoxin family. | 0.511 |
| coiA | clpX | Ldb0582 | Ldb0778 | Putative competence protein CoiA (fragment). | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.409 |
| coiA | mecA | Ldb0582 | Ldb0579 | Putative competence protein CoiA (fragment). | Negative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | 0.629 |
| coiA | spx | Ldb0582 | Ldb0578 | Putative competence protein CoiA (fragment). | Conserved hypothetical protein (ArsC family); Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. | 0.685 |
| mecA | Ldb1354 | Ldb0579 | Ldb1354 | Negative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | 0.497 |
| mecA | clpP | Ldb0579 | Ldb0624 | Negative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.705 |
| mecA | clpX | Ldb0579 | Ldb0778 | Negative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.417 |
| mecA | coiA | Ldb0579 | Ldb0582 | Negative regulator of competence MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | Putative competence protein CoiA (fragment). | 0.629 |
