| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ldb0339 | Ldb1363 | Ldb0339 | Ldb1363 | Putative dCMP deaminase. | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.904 |
| Ldb0339 | dut | Ldb0339 | Ldb1728 | Putative dCMP deaminase. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.934 |
| Ldb0339 | tdk | Ldb0339 | Ldb0700 | Putative dCMP deaminase. | Thymidine kinase. | 0.921 |
| Ldb0339 | thyA | Ldb0339 | Ldb0787 | Putative dCMP deaminase. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.925 |
| Ldb0339 | tmk | Ldb0339 | Ldb1631 | Putative dCMP deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.977 |
| Ldb1363 | Ldb0339 | Ldb1363 | Ldb0339 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Putative dCMP deaminase. | 0.904 |
| Ldb1363 | dut | Ldb1363 | Ldb1728 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
| Ldb1363 | thyA | Ldb1363 | Ldb0787 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
| Ldb1363 | tmk | Ldb1363 | Ldb1631 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.917 |
| dut | Ldb0339 | Ldb1728 | Ldb0339 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative dCMP deaminase. | 0.934 |
| dut | Ldb1363 | Ldb1728 | Ldb1363 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.900 |
| dut | rtpR | Ldb1728 | Ldb0096 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Ribonucleoside-triphosphate reductase; Belongs to the class II ribonucleoside-triphosphate reductase family. | 0.960 |
| dut | tdk | Ldb1728 | Ldb0700 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.957 |
| dut | thyA | Ldb1728 | Ldb0787 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.957 |
| dut | tmk | Ldb1728 | Ldb1631 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.950 |
| folA | folC1 | Ldb0788 | Ldb0728 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.932 |
| folA | folC2 | Ldb0788 | Ldb0248 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.947 |
| folA | folD | Ldb0788 | Ldb1425 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methylenetetrahydrofolate dehydrogenase / Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.469 |
| folA | thyA | Ldb0788 | Ldb0787 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| folA | tmk | Ldb0788 | Ldb1631 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.401 |
