| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ldb0339 | Ldb1363 | Ldb0339 | Ldb1363 | Putative dCMP deaminase. | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.904 |
| Ldb0339 | dut | Ldb0339 | Ldb1728 | Putative dCMP deaminase. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.950 |
| Ldb0339 | tdk | Ldb0339 | Ldb0700 | Putative dCMP deaminase. | Thymidine kinase. | 0.929 |
| Ldb0339 | thyA | Ldb0339 | Ldb0787 | Putative dCMP deaminase. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.943 |
| Ldb0339 | tmk | Ldb0339 | Ldb1631 | Putative dCMP deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.980 |
| Ldb1363 | Ldb0339 | Ldb1363 | Ldb0339 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Putative dCMP deaminase. | 0.904 |
| Ldb1363 | dut | Ldb1363 | Ldb1728 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
| Ldb1363 | tdk | Ldb1363 | Ldb0700 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.903 |
| Ldb1363 | thyA | Ldb1363 | Ldb0787 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
| Ldb1363 | tmk | Ldb1363 | Ldb1631 | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.911 |
| alr | thyA | Ldb0360 | Ldb0787 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.809 |
| dut | Ldb0339 | Ldb1728 | Ldb0339 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative dCMP deaminase. | 0.950 |
| dut | Ldb1363 | Ldb1728 | Ldb1363 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Putative secreted 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.900 |
| dut | folA | Ldb1728 | Ldb0788 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.424 |
| dut | tdk | Ldb1728 | Ldb0700 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.969 |
| dut | thyA | Ldb1728 | Ldb0787 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | D-isomer specific 2-hydroxyacid dehydrogenase (fragment); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.972 |
| dut | tmk | Ldb1728 | Ldb1631 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.948 |
| folA | dut | Ldb0788 | Ldb1728 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.424 |
| folA | folC1 | Ldb0788 | Ldb0728 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.938 |
| folA | folC2 | Ldb0788 | Ldb0248 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.962 |
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