| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ldb1540 | mutL | Ldb1540 | Ldb1615 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.533 |
| Ldb1540 | pcrA | Ldb1540 | Ldb0465 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | ATP-dependent DNA helicase PcrA. | 0.629 |
| Ldb1540 | polA | Ldb1540 | Ldb1512 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.991 |
| Ldb1540 | recA | Ldb1540 | Ldb0599 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | RecA protein (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.705 |
| Ldb1540 | recD | Ldb1540 | Ldb0758 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Exodeoxyribonuclease V alpha chain; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.574 |
| Ldb1540 | recJ | Ldb1540 | Ldb1309 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | RecJ, single-stranded DNA specific exonuclease. | 0.720 |
| Ldb1540 | recQ | Ldb1540 | Ldb0814 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | ATP-dependent DNA helicase RecQ. | 0.760 |
| Ldb1540 | topA | Ldb1540 | Ldb1273 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.461 |
| cshA | recQ | Ldb0358 | Ldb0814 | ATP-dependent helicase (DEAD/DEAH box family); DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. | ATP-dependent DNA helicase RecQ. | 0.924 |
| gmk1 | polA | Ldb1415 | Ldb1512 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.543 |
| gmk1 | recQ | Ldb1415 | Ldb0814 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | ATP-dependent DNA helicase RecQ. | 0.888 |
| gmk1 | topA | Ldb1415 | Ldb1273 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.432 |
| mutL | Ldb1540 | Ldb1615 | Ldb1540 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | 0.533 |
| mutL | pcrA | Ldb1615 | Ldb0465 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | ATP-dependent DNA helicase PcrA. | 0.786 |
| mutL | polA | Ldb1615 | Ldb1512 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.956 |
| mutL | recA | Ldb1615 | Ldb0599 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | RecA protein (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.839 |
| mutL | recD | Ldb1615 | Ldb0758 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Exodeoxyribonuclease V alpha chain; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. | 0.442 |
| mutL | recJ | Ldb1615 | Ldb1309 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | RecJ, single-stranded DNA specific exonuclease. | 0.806 |
| mutL | recQ | Ldb1615 | Ldb0814 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | ATP-dependent DNA helicase RecQ. | 0.744 |
| mutL | topA | Ldb1615 | Ldb1273 | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.606 |
